MacGregor R R
Infectious Diseases Section, University of Pennsylvania, School of Medicine, Philadelphia.
Chemotherapy. 1991;37 Suppl 2:53-7. doi: 10.1159/000238920.
Imipenem is the broadest-spectrum antibiotic currently available but requires frequent intravenous dosing for efficacy. A recently formulated finely milled preparation can be given intramuscularly in small volumes and demonstrates kinetics favorable for 12-hourly intramuscular administration. The intramuscular imipenem formulation has been proven to be effective for mild to moderate infections of many body sites, as demonstrated by other papers in this symposium. The advantages of intramuscular administration include: less frequent dosing, avoidance of the complications of intravenous administration (phlebitis, bacteremia, fluid overload, nursing time), ability to use the drug in settings where intravenous administration is either undesirable or impossible and, surprising to medical personnel, greater patient satisfaction.
亚胺培南是目前可用的光谱最广的抗生素，但为达到疗效需要频繁静脉给药。最近配制的精细研磨制剂可小剂量肌肉注射，其动力学特性有利于每12小时进行一次肌肉注射。本次研讨会的其他论文表明，肌肉注射用亚胺培南制剂已被证明对身体多个部位的轻至中度感染有效。肌肉注射给药的优点包括：给药频率较低、避免静脉给药的并发症（静脉炎、菌血症、液体过载、护理时间）、能够在静脉给药不可取或不可能的情况下使用该药物，而且令医务人员惊讶的是，患者满意度更高。
