Shabb N, Sneige N, Fanning C V, Dekmezian R
Department of Pathology, University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030.
Diagn Cytopathol. 1991;7(3):293-8. doi: 10.1002/dc.2840070317.
Alveolar soft-part sarcoma (ASPS) is a rare soft-tissue tumor. Few cases have been reported in the aspiration cytology literature. We discuss the fine-needle aspiration (FNA) cytologic features of ASPS in four patients. The smears were characterized by single cells and clusters of cells associated with thin-walled vasculature, resulting in a distinct pseudoalveolar pattern. The cells had abundant granular cytoplasm and large round nuclei with prominent central nucleoli. Binucleated and occasional multinucleated cells were present. Numerous stripped tumor nuclei were a consistent feature. Periodic acid-Schiff (PAS)-positive diastase-resistant granules were demonstrable within the intact and fragmented cytoplasm. Electron microscopy of aspirated material identified granules and crystals with the characteristic lattice pattern. To conclude, the FNA cytologic features of ASPS are characteristic. Confirmation by special stains and electron microscopy of FNA material is possible. The differential diagnostic considerations include renal cell carcinoma, paraganglioma, granular cell tumor, clear cell sarcoma, and epithelioid sarcoma.
肺泡软组织肉瘤（ASPS）是一种罕见的软组织肿瘤。在细针穿刺细胞学文献中报道的病例很少。我们讨论了4例ASPS患者的细针穿刺（FNA）细胞学特征。涂片的特征是单个细胞和成簇细胞与薄壁脉管系统相关，形成独特的假腺泡模式。细胞具有丰富的颗粒状细胞质和大的圆形细胞核，核仁明显。存在双核及偶尔的多核细胞。大量游离的肿瘤细胞核是一个恒定特征。在完整和破碎的细胞质内可显示过碘酸希夫（PAS）阳性、抗淀粉酶颗粒。对穿刺材料进行电子显微镜检查可识别具有特征性晶格图案的颗粒和晶体。总之，ASPS的FNA细胞学特征具有特异性。通过对FNA材料进行特殊染色和电子显微镜检查可以确诊。鉴别诊断需考虑肾细胞癌、副神经节瘤、颗粒细胞瘤、透明细胞肉瘤和上皮样肉瘤。
