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[Induction of differentiation of human T-cell leukemic cell line (CEM) by phorbol ester].

作者信息

Yao X R

机构信息

Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing.

出版信息

Zhonghua Zhong Liu Za Zhi. 1991 Mar;13(2):114-6.

PMID:1879288
Abstract

In the present study, we investigated the effect of phorbol 12-myristate 13-acetate (PMA) on induction of differentiation of human T-cell leukemic cell line (CEM). The results showed that uninduced cells were T1+, T4+, T9+, T10+, T3- and TcR-, representing thymus stage II differentiation. When culturing in vitro with PMA for 5 to 7 days, CEM cells expressed mature T-cell marker (T3) whereas the percentage of cells expressing proliferation-association antigen (T9) was markedly decreased. In addition, PMA could significantly inhibit the growth of CEM cells. We also found that after co-culture with PMA for 2 to 3 days, CEM cells showed distinct morphologic changes. These findings indicate that PMA may induce CEM cells to differentiate towards mature stage.

摘要

相似文献

1
[Induction of differentiation of human T-cell leukemic cell line (CEM) by phorbol ester].
Zhonghua Zhong Liu Za Zhi. 1991 Mar;13(2):114-6.
2
Differentiation of human T-lymphoid leukemia cells into cells that have a suppressor phenotype is induced by phorbol 12-myristate 13-acetate.佛波醇12 - 肉豆蔻酸酯13 - 乙酸酯可诱导人T淋巴细胞白血病细胞分化为具有抑制表型的细胞。
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Cell differentiation and altered IMP dehydrogenase expression induced in human T-lymphoblastoid leukemia cells by mycophenolic acid and tiazofurin.霉酚酸和硫唑嘌呤在人T淋巴母细胞白血病细胞中诱导的细胞分化及肌苷酸脱氢酶表达改变
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Divergent effects of bryostatin 1 and phorbol myristate acetate on cell cycle arrest and maturation in human myelomonocytic leukemia cells (U937).苔藓抑素1和佛波醇肉豆蔻酸酯乙酸盐对人骨髓单核细胞白血病细胞（U937）细胞周期阻滞和成熟的不同影响。
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引用本文的文献

1
Prosomes (proteasomes) changes during differentiation are related to the type of inducer.前体（蛋白酶体）在分化过程中的变化与诱导剂的类型有关。
Mol Biol Rep. 1997 Mar;24(1-2):57-62. doi: 10.1023/a:1006856707793.