Alex S, Criado C, Fernández-Guerrero M L, de Górgolas M, Petkov V, Garcia Perez A, Egido J, Barat A, Manzarbeitia F, Caramelo C, Ortiz A
Department of Nephrology, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Spain.
Clin Nephrol. 2008 Jul;70(1):65-8. doi: 10.5414/cnp70065.
Leishmania infection may be associated with immunecomplex-mediated glomerular injury. Contrary to immune-competent individuals, leishmaniasis in HIV patients is a chronic, relapsing disease. Despite the increasing frequency of the Leishmania/ HIV co-infection, there is a paucity of information on the effects of such co-infection in the kidney. We present a patient with AIDS and refractory, relapsing visceral leishmaniasis who developed nephrotic syndrome associated with renal involvement by Leishmania in the absence of immunecomplex glomerular deposition. For the first time, the relapsing nature of renal injury in this context is documented.
利什曼原虫感染可能与免疫复合物介导的肾小球损伤有关。与免疫功能正常的个体不同，HIV患者的利什曼病是一种慢性复发性疾病。尽管利什曼原虫/HIV合并感染的频率不断增加，但关于这种合并感染对肾脏影响的信息却很少。我们报告了一名患有艾滋病和难治性复发性内脏利什曼病的患者，该患者在没有免疫复合物肾小球沉积的情况下出现了与利什曼原虫肾脏受累相关的肾病综合征。首次记录了这种情况下肾损伤的复发性。
