Alberga A, Boulay J L, Kempe E, Dennefeld C, Haenlin M
Laboratoire de Génetique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique, Unité 184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Faculté de Médicine, Strasbourg, France.
Development. 1991 Apr;111(4):983-92. doi: 10.1242/dev.111.4.983.
The zygotic effect gene snail (sna) encodes a zinc-finger protein required for mesoderm formation in Drosophila embryos. By in situ analysis, sna transcripts are first detected at syncytial blastoderm and persist until very late stages of embryogenesis. Expression of sna is transient and is observed in tissues derived from all three germ layers. Prior to germband elongation, sna RNA accumulation is consistent with its genetically determined role in mesoderm formation. Starting at germband elongation, a second phase of sna expression appears to be initiated, characterized by a highly dynamic accumulation of transcripts in the developing central and peripheral nervous systems. Translation of sna RNA is apparently delayed as the sna protein is not detected before the onset of gastrulation. Its regional distribution generally correlates with that of sna transcripts. The complex pattern of sna expression strongly suggests that the function of the gene is not restricted to mesoderm formation.
合子效应基因蜗牛（sna）编码一种果蝇胚胎中中胚层形成所需的锌指蛋白。通过原位分析，sna转录本首先在合胞体胚盘被检测到，并持续到胚胎发生的非常晚期。sna的表达是短暂的，在来自所有三个胚层的组织中都能观察到。在胚带伸长之前，sna RNA的积累与其在中胚层形成中的遗传决定作用一致。从胚带伸长开始，sna表达的第二阶段似乎被启动，其特征是转录本在发育中的中枢和外周神经系统中高度动态积累。sna RNA的翻译明显延迟，因为在原肠胚形成开始之前未检测到sna蛋白。其区域分布通常与sna转录本的分布相关。sna表达的复杂模式强烈表明该基因的功能不限于中胚层形成。
