Verwoerd-Dikkeboom Christine M, van Heesch Peter N A C M, Koning Anton H J, Galjaard Robert-Jan H, Exalto Niek, Steegers Eric A P
Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Fertil Steril. 2008 Nov;90(5):2017.e19-22. doi: 10.1016/j.fertnstert.2008.07.1721. Epub 2008 Sep 14.
To demonstrate the use of a novel three-dimensional (3D) virtual reality (VR) system in the visualization of first trimester growth and development in a case of confined placental trisomy 16 mosaicism (CPM+16).
Case report.
Prospective study on first trimester growth using a 3D VR system.
PATIENT(S): A 34-year-old gravida 1, para 0 was seen weekly in the first trimester for 3D ultrasound examinations.
INTERVENTION(S): Chorionic villus sampling was performed because of an enlarged nuchal translucency (NT) measurement and low pregnancy-associated plasma protein-A levels, followed by amniocentesis.
RESULT(S): Amniocentesis revealed a CPM+16. On two-dimensional (2D) and 3D ultrasound no structural anomalies were found with normal fetal Dopplers. Growth remained below the 2.3 percentile. At 37 weeks, a female child of 2010 g (<2.5 percentile) was born. After birth, growth climbed to the 50th percentile in the first 2 months.
CONCLUSION(S): The I-Space VR system provided information about phenotypes not obtainable by standard 2D ultrasound. In this case, the delay in growth and development could be observed very early in pregnancy. Since first trimester screening programs are still improving and becoming even more important, systems such as the I-Space open a new era for in vivo studies on the physiologic and pathologic processes involved in embryogenesis.
展示一种新型三维（3D）虚拟现实（VR）系统在局限性胎盘16三体镶嵌症（CPM+16）病例中孕早期生长发育可视化方面的应用。
病例报告。
使用3D VR系统对孕早期生长进行的前瞻性研究。
一名34岁初产妇，孕1产0，在孕早期每周接受一次3D超声检查。
因颈部透明带（NT）测量值增大及妊娠相关血浆蛋白A水平降低而进行绒毛取样，随后进行羊膜穿刺术。
羊膜穿刺术显示为CPM+16。二维（2D）和3D超声检查均未发现结构异常，胎儿多普勒检查正常。生长仍低于第2.3百分位数。37周时，一名体重2010克（<第2.5百分位数）的女婴出生。出生后，头两个月生长升至第50百分位数。
I-Space VR系统提供了标准2D超声无法获得的有关表型的信息。在此病例中，孕早期就能观察到生长发育延迟。由于孕早期筛查项目仍在不断改进且变得更加重要，I-Space等系统为胚胎发生过程中生理和病理过程的体内研究开启了一个新时代。
