5-氟尿嘧啶：耐药机制与逆转策略
5-Fluorouracil: mechanisms of resistance and reversal strategies.
作者信息
Zhang Ning, Yin Ying, Xu Sheng-Jie, Chen Wei-Shan
机构信息
Department of Orthopaedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, 310009, P.R. China.
出版信息
Molecules. 2008 Aug 5;13(8):1551-69. doi: 10.3390/molecules13081551.
The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of anti-tumor action, studies of the resistance to the drug, and procedures for the identification of new genes involved in resistance with microarray techniques. The details of the induction and reversal of the drug resistance are also described.
这项工作的目的是回顾已发表的关于5-氟尿嘧啶作用机制和耐药性的研究。该综述分为三个主要部分：抗肿瘤作用机制、对该药物耐药性的研究以及用微阵列技术鉴定参与耐药性的新基因的程序。还描述了耐药性的诱导和逆转细节。
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