肾素-血管紧张素系统阻断与糖尿病：将脂肪器官从外周转移至中心。

Renin-angiotensin system blockade and diabetes: moving the adipose organ from the periphery to the center.

作者信息

Lenz Oliver, Fornoni Alessia

机构信息

Division of Nephrology and Hypertension, Department of Medicine, University of Miami Leonard Miller School of Medicine, Miami, Florida 33136, USA.

出版信息

Kidney Int. 2008 Oct;74(7):851-3. doi: 10.1038/ki.2008.391.

DOI:10.1038/ki.2008.391

PMID:18794817

Abstract

Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.

摘要

李等人报告称，血管紧张素II 1型受体阻滞剂（ARB）改善了OLETF大鼠（一种2型糖尿病实验模型）的葡萄糖不耐受情况。ARB治疗导致脂肪组织发生调节变化，使得能够产生更多脂联素、更少单核细胞趋化蛋白-1和纤溶酶原激活物抑制剂-1的小的、已分化脂肪细胞数量增加。这支持了在胰岛素抵抗状态下脂肪组织与肾素-血管紧张素系统之间功能相互作用的相关性。