Yoshida Ryuichi, Iwamoto Takayuki, Yagi Takahito, Sato Daisuke, Umeda Yuzo, Mizuno Kenji, Shinoura Susumu, Matsukawa Hiroyoshi, Matsuda Hiroaki, Sadamori Hiroshi, Tanaka Noriaki
Department of Gastroenterological Transplant Surgery and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, 2-5-1, Shikata-Cyo, Okayama City, 700-8558, Okayama, Japan.
World J Surg. 2008 Nov;32(11):2419-24. doi: 10.1007/s00268-008-9715-5.
The purpose of this study was to analyze various risk factors and to assess the preoperative risk score, which can predict the prognosis after living donor liver transplantation (LDLT).
From February 2002 to August 2007, 84 adult to adult living donor liver transplantation donors and recipients were analyzed. First, the donor, recipient, and intraoperative factors were examined by univariate and multivariate analyses. We then gave a score of one point for each significant marginal factor (total point scores were called "risk score") and each risk score was examined by univariate analyses.
Recipients with the donor age 50 years or older, Model for End-Stage Liver Disease (MELD) score (> or =21), and hepatitis C virus-positive status had a significantly poor survival. Recipients between the risk score of 0 vs. scores of 2 + 3 (p < 0.001, log-rank) and risk score of 1 vs. scores of 2 + 3 (p = 0.003, log-rank) had significantly different survival.
Preoperative assessment of the risk score might help to predict recipient outcomes after living donor liver transplantation.
本研究旨在分析各种风险因素并评估术前风险评分，该评分可预测活体肝移植（LDLT）后的预后。
对2002年2月至2007年8月期间的84例成人对成人活体肝移植供受者进行分析。首先，通过单因素和多因素分析检查供者、受者及术中因素。然后，对每个显著边缘因素计1分（总分称为“风险评分”），并通过单因素分析检查每个风险评分。
供者年龄50岁及以上、终末期肝病模型（MELD）评分（≥21）以及丙型肝炎病毒阳性的受者生存率显著较差。风险评分为0与2 + 3分的受者（p < 0.001，对数秩检验）以及风险评分为1与2 + 3分的受者（p = 0.003，对数秩检验）的生存率有显著差异。
术前评估风险评分可能有助于预测活体肝移植后受者的预后。
