Reina-Romo E, Gómez-Benito M J, García-Aznar J M, Domínguez J, Doblaré M
Department of Mechanical Engineering, University of Seville, 41092, Seville, Spain.
Biomech Model Mechanobiol. 2009 Aug;8(4):323-35. doi: 10.1007/s10237-008-0138-x. Epub 2008 Sep 16.
Distraction osteogenesis is a useful technique aimed at inducing bone formation in widespread clinical applications. One of the most important factors that conditions the success of bone regeneration is the distraction rate. Since the mechanical environment around the osteotomy site is one of the main factors that affects both quantity and quality of the regenerated bone, we have focused on analyzing how the distraction rate influences on the mechanical conditions and tissue regeneration. Therefore, the aim of the present work is to explore the potential of a mathematical algorithm to simulate clinically observed distraction rate related phenomena that occur during distraction osteogenesis. Improvements have been performed on a previous model (Gómez-Benito et al. in J Theor Biol 235:105-119, 2005) in order to take into account the load history. The results obtained concur with experimental findings: a slow distraction rate results in premature bony union, whereas a fast rate results in a fibrous union. Tension forces in the interfragmentary gap tissue have also been estimated and successfully compared with experimental measurements.
牵张成骨是一种在广泛临床应用中用于诱导骨形成的有用技术。决定骨再生成功的最重要因素之一是牵张速率。由于截骨部位周围的力学环境是影响再生骨数量和质量的主要因素之一，我们专注于分析牵张速率如何影响力学条件和组织再生。因此，本研究的目的是探索一种数学算法模拟牵张成骨过程中临床观察到的与牵张速率相关现象的潜力。为了考虑载荷历史，对先前的模型（Gómez - Benito等人，《理论生物学杂志》235:105 - 119，2005年）进行了改进。所得结果与实验结果一致：牵张速率慢会导致过早骨愈合，而速率快则会导致纤维性愈合。还对骨碎片间隙组织中的张力进行了估计，并成功地与实验测量值进行了比较。
