Lazarevic Gordana, Antic Slobodan, Cvetkovic Tatjana, Djordjevic Vidosava, Vlahovic Predag, Stefanovic Vladisav
Clinic of Cardiovascular Diseases, Clinical Centre, Nis, Serbia.
Acta Cardiol. 2008 Aug;63(4):485-91. doi: 10.2143/AC.63.4.2033048.
The aim of the present study was to investigate not only the effects of aerobic exercise on overall cardiovascular risk factors profile and oxidative stress in obese, type 2 diabetic patients, but to elucidate if those effects depended on the previously estimated Systematic Coronary Risk Evaluation (SCORE) risk.
Changes in several well-established cardiovascular risk factors and oxidative stress-defense parameters were measured in a total of 30 previously sedentary, obese type 2 diabetic patients, including 16 low-risk (SCORE < 5%, aged 48.8 +/- 6.0 years, with a mean BMI of 33.28 +/- 2.94 kg/m2) and 14 high-risk (SCORE > or = 5%, aged 56.3 +/- 6.9 years, with a mean BMI of 31.40 +/- 1.13 kg/m2) patients, in regard to the SCORE model, during six months of regular aerobic exercise, performed under supervision.
Significant improvement was observed in the majority of cardiovascular risk factors, including body mass index, waist circumference, blood pressure, glycaemia, glycated haemoglobin, median blood glucose and lipid profile parameters in both diabetic subgroups during the exercise programme. However, the benefits of exercise on the majority of examined parameters became more evident in the low-risk subgroup, compared to the high-risk subgroup from baseline to 3 months. Regular exercise markedly reduced oxidative stress in both subgroups as well, as demonstrated for glutathione, plasma malondialdehyde, sulphydryl groups and catalase.
Regular aerobic exercise, performed under supervision, has many beneficial effects in improving overall cardiovascular risk factors profile and reducing oxidative stress in both low-risk and high-risk (according to SCORE model), previously sedentary and obese type 2 diabetic patients.
本研究的目的不仅是调查有氧运动对肥胖的2型糖尿病患者整体心血管危险因素状况及氧化应激的影响，还要阐明这些影响是否取决于先前估计的系统性冠状动脉风险评估（SCORE）风险。
在总共30名先前久坐不动的肥胖2型糖尿病患者中，测量了几个公认的心血管危险因素及氧化应激防御参数的变化，其中包括16名低风险患者（SCORE<5%，年龄48.8±6.0岁，平均体重指数为33.28±2.94kg/m²）和14名高风险患者（SCORE≥5%，年龄56.3±6.9岁，平均体重指数为31.40±1.13kg/m²），依据SCORE模型，在监督下进行为期六个月的规律有氧运动。
在运动计划期间，两个糖尿病亚组的大多数心血管危险因素均有显著改善，包括体重指数、腰围、血压、血糖、糖化血红蛋白、平均血糖和血脂谱参数。然而，从基线到3个月，与高风险亚组相比，运动对大多数检测参数的益处在低风险亚组中更为明显。规律运动也显著降低了两个亚组的氧化应激，如谷胱甘肽、血浆丙二醛、巯基和过氧化氢酶所示。
在监督下进行的规律有氧运动，对改善低风险和高风险（根据SCORE模型）、先前久坐不动的肥胖2型糖尿病患者的整体心血管危险因素状况及降低氧化应激有诸多有益作用。
