Chen Yang-Xin, Wang Xiao-Qiao, Fang Chong-Feng, Wang Jing-Feng, Tang Li-Jiang
Department of Cardiology, the Second Affiliated Hospital of Sun Yat-sen University, Guangzhou Guangdong, People's Republic of China.
Acta Cardiol. 2008 Aug;63(4):501-6. doi: 10.2143/AC.63.4.2033050.
The objective was to study the association between B-type natriuretic peptide (BNP) and tumour markers and heart failure (HF) to evaluate the value of BNP and carbohydrate antigen 125 (CA125) in HF patients.
A university hospital-based cross-over study of 285 subjects (157 men and 128 women) in HF, chronic obstructive pulmonary disease (COPD), mild-mid pulmonary hypertension patients and control subjects.
CA125 and BNP were significantly higher in the HF group than in the non-HF group and in severe HF than in mild HF (P < 0.01). No changes were observed in other tumour markers. CA125 and BNP decreased obviously after clinical improvement by aggressive treatment (P < 0.01). Left ventricular ejection fraction correlated positively with CA125 (r = 0.789, P < 0.01) and BNP (r = 0.730, P < 0.01) in left heart failure patients, but not in other patients. BNP and CA125 had better accuracy and positive predictive value in diagnosing HF from the characteristic receiver-operator curve.
CA125 and BNP are markedly elevated in heart failure and closely reflect heart function. They are better markers in evaluating the efficiency of short-term therapy. Detecting BNP combined with CA125 may be more valuable than only detecting BNP or CA125 for diagnosing HF and evaluating the efficiency of treatment.
研究B型利钠肽（BNP）与肿瘤标志物及心力衰竭（HF）之间的关联，以评估BNP和糖类抗原125（CA125）在HF患者中的价值。
一项基于大学医院的交叉研究，纳入了285名受试者（157名男性和128名女性），包括HF、慢性阻塞性肺疾病（COPD）、轻中度肺动脉高压患者及对照受试者。
HF组的CA125和BNP显著高于非HF组，重度HF患者高于轻度HF患者（P<0.01）。其他肿瘤标志物未见变化。积极治疗使临床症状改善后，CA125和BNP明显下降（P<0.01）。在左心衰竭患者中，左心室射血分数与CA125（r=0.789，P<0.01）和BNP（r=0.730，P<0.01）呈正相关，但在其他患者中无此相关性。从特征性的受试者工作特征曲线来看，BNP和CA125在诊断HF方面具有更好的准确性和阳性预测价值。
CA125和BNP在心力衰竭时显著升高，并密切反映心脏功能。它们是评估短期治疗效果的更好标志物。联合检测BNP和CA125在诊断HF及评估治疗效果方面可能比单独检测BNP或CA125更有价值。
