Nishimukai H, Shiraishi S, Shirakata Y, Sayama K, Shinomiya T, Miki Y
Department of Legal Medicine, Ehime University, Japan.
Dermatologica. 1991;182(3):164-7. doi: 10.1159/000247770.
The allotypes of C6, C7, factor B (BF) and factor I (IF) of the human complement system were studied in 11 Japanese patients with pemphigus (5 with pemphigus vulgaris and 6 with pemphigus foliaceus) and 17 with bullous pemphigoid (BP) to investigate the genetic background of these diseases. The allotypes were detected by using isoelectric focusing and immunoblotting. The frequency for IF*A allele in the pemphigus patients was significantly higher (p = 0.009) than that in healthy controls (n = 60). A significant association of IF A allotype with pemphigus was also observed (p = 0.027), with a relative risk of 6.3. There was no association between the C6, C7, BF or IF allotypes and BP. These data suggest that IF A allotype may be an etiological genetic factor in the development of pemphigus.
为研究天疱疮和大疱性类天疱疮的遗传背景，我们对11例日本天疱疮患者（5例寻常型天疱疮和6例落叶型天疱疮）和17例大疱性类天疱疮（BP）患者的人类补体系统C6、C7、B因子（BF）和I因子（IF）的同种异型进行了研究。通过等电聚焦和免疫印迹法检测同种异型。天疱疮患者中IF*A等位基因的频率显著高于健康对照者（n = 60）（p = 0.009）。还观察到IF A同种异型与天疱疮之间存在显著关联（p = 0.027），相对风险为6.3。C6、C7、BF或IF同种异型与BP之间无关联。这些数据表明，IF A同种异型可能是天疱疮发病的一个病因学遗传因素。
