Fenwick J C, Brasseur J G
Department of Biology, University of Ottawa, Ontario, Canada.
Gen Comp Endocrinol. 1991 Jun;82(3):459-65. doi: 10.1016/0016-6480(91)90321-v.
Intraperitoneal injection of CaCl2 in intact, sham-stanniectomized, and stanniectomized American eels, Anguilla rostrata (LeSueur), resulted in a rapid elevation of plasma calcium level which was more marked and of longer duration in the stanniectomized eels. The same treatment reduced whole body calcium influx (JinCa2+) in the intact and sham-stanniectomized groups for the first but not the second of two 4 hr flux periods. The same treatment did not affect JinCa2+ in the stanniectomized eels. We conclude that calcium loading in eels with intact stannius corpuscles (CS) results in the release of a CS hormone (stanniocalcin) which inhibits the uptake of calcium from the environment and that this facilitates the return to normocalcemia. These data provide direct evidence for a relationship between stanniocalcin release in vivo and a hypocalcemic response and the first evidence concerning the functional turnover time of this hormone.
对完整的、假手术切除斯坦尼小体的和切除斯坦尼小体的美洲鳗鲡（Anguilla rostrata，LeSueur）进行腹腔注射氯化钙后，血浆钙水平迅速升高，切除斯坦尼小体的鳗鲡中这种升高更为显著且持续时间更长。相同处理使完整组和假手术切除斯坦尼小体组在两个4小时通量期的第一个（而非第二个）期间全身钙流入量（JinCa2+）降低。相同处理对切除斯坦尼小体的鳗鲡的JinCa2+没有影响。我们得出结论，具有完整斯坦尼小体（CS）的鳗鲡钙负荷会导致CS激素（鲽鱼降钙素）释放，该激素抑制从环境中摄取钙，这有助于恢复正常血钙水平。这些数据为体内鲽鱼降钙素释放与低钙血症反应之间的关系提供了直接证据，也是关于该激素功能周转时间的首个证据。
