Semaan Maroun T, Megerian Cliff A
House Ear Institute and House Ear Clinic, Los Angeles, California, USA.
Curr Opin Otolaryngol Head Neck Surg. 2008 Oct;16(5):420-6. doi: 10.1097/MOO.0b013e32830c4595.
To provide an overview on the recent advances in the diagnosis and treatment of glomus tumors (paragangliomas).
The review focuses on the genetics of paragangliomas and discusses the role of newer therapeutic modalities in the management of jugulotympanic paragangliomas.
Recent advances in the field of genetics allowed the identification of three main loci involved in hereditary paragangliomas. Genetic screening of patients with family history identifies affected individuals. The management of glomus tumors continues to be a challenging task. Surgery remains the mainstay of treatment for young healthy patients with functional cranial nerve deficits. Gamma knife radiosurgery is offered as an adjunctive to limited surgery and as the primary treatment modality in poor surgical candidates or patients with bilateral disease.
概述球瘤（副神经节瘤）诊断与治疗的最新进展。
本综述聚焦于副神经节瘤的遗传学，并讨论了新型治疗方式在颈静脉鼓室副神经节瘤管理中的作用。
遗传学领域的最新进展使得能够识别出与遗传性副神经节瘤相关的三个主要基因座。对有家族史的患者进行基因筛查可确定受影响个体。球瘤的管理仍然是一项具有挑战性的任务。对于有功能性颅神经缺损的年轻健康患者，手术仍是主要治疗方法。伽玛刀放射外科手术可作为有限手术的辅助手段，以及手术风险高或双侧病变患者的主要治疗方式。
