Schey Ron, Shapiro Michael, Navarro-Rodriguez Tomas, Fass Shira S, Han Bing, Wendel Christopher, Fass Ronnie
Section of Gastroenterology, Department of Medicine, The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care, Tucson, AZ, USA.
J Clin Gastroenterol. 2009 Sep;43(8):699-704. doi: 10.1097/MCG.0b013e318182673f.
Presently, there are no studies comparing sensed acid reflux event (SARE) characteristics among different heartburn groups. Our aim was to compare the different esophageal acid reflux characteristics of an SARE among the different heartburn groups.
Patients with heartburn underwent endoscopy and pH testing and were stratified into 3 groups: erosive esophagitis (EE), nonerosive reflux disease (NERD), and functional heartburn (FH). Patients underwent esophageal pH testing using a 4-sensor pH probe, with the most distal pH sensor positioned 1 cm> lower esophageal sphincter (LES).
Twenty-two patients had EE, 15 NERD, and 13 FH (M/F: 20/2, 12/3, 5/8, mean age: 51.5+/-3.7, 50.1+/-4.2, 50.3+/-3.8, respectively). The percentage of SAREs at 1 cm>LES that had reached 16 cm>LES was significantly higher in the FH group compared with NERD and EE (P<0.05). EE demonstrated the lowest nadir during an SARE and NERD the most acid reflux events before an SARE (up to 4 h).
Patients with FH demonstrated the most SAREs that reached the proximal esophagus. EE patients demonstrated the lowest nadir pH during an SARE and NERD patients the most acid reflux events before an SARE, as compared with the other heartburn groups.
目前，尚无研究比较不同烧心组之间的感知性酸反流事件（SARE）特征。我们的目的是比较不同烧心组之间SARE的不同食管酸反流特征。
有烧心症状的患者接受了内镜检查和pH测试，并被分为3组：糜烂性食管炎（EE）、非糜烂性反流病（NERD）和功能性烧心（FH）。患者使用4传感器pH探头进行食管pH测试，最远端的pH传感器位于食管下括约肌（LES）下方1 cm处。
22例患者为EE，15例为NERD，13例为FH（男/女：20/2、12/3、5/8，平均年龄：分别为51.5±3.7、50.1±4.2、50.3±3.8）。与NERD和EE组相比，FH组中在LES下方1 cm处发生的SARE到达LES上方16 cm处的百分比显著更高（P<0.05）。EE组在SARE期间的最低点pH值最低，NERD组在SARE之前的酸反流事件最多（长达4小时）。
与其他烧心组相比，FH患者发生的到达食管近端的SARE最多。EE患者在SARE期间的最低点pH值最低，NERD患者在SARE之前的酸反流事件最多。
