Martinelli Carlos Eduardo, Custódio Rodrigo José, Aguiar-Oliveira Manuel Hermínio
Departamento de Puericultura e Pediatria, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, SP, Brazil.
Arq Bras Endocrinol Metabol. 2008 Jul;52(5):717-25. doi: 10.1590/s0004-27302008000500002.
Growth, the main characteristic of childhood and adolescence, has a similar pattern in the majority of the individuals. Genetic background and GH-IGF axis are the factors that directly influence this process. Pituitary GH acts on growth mainly through the regulation of IGF system. The IGFs (IGF-1 and IGF-2) are growth factors produced in the majority of the organs and body tissues. They have autocrine, paracrine and endocrine actions on metabolism and cell proliferation, growth and differentiation. The IGFs bind with high specificity and affinity to a family of 6 binding proteins, called IGFBPs (1 to 6) that modulate their bioactivity. Most of the known IGF actions are mediated via IGF type 1 receptor (IGF1R). In this article we are going to review the composition and regulation of the GH-IGF axis and the role of each component in the regulation of the growth process.
生长是儿童期和青春期的主要特征，大多数个体的生长模式相似。遗传背景和生长激素-胰岛素样生长因子轴是直接影响这一过程的因素。垂体生长激素主要通过调节胰岛素样生长因子系统来作用于生长。胰岛素样生长因子（IGF-1和IGF-2）是在大多数器官和身体组织中产生的生长因子。它们对代谢以及细胞增殖、生长和分化具有自分泌、旁分泌和内分泌作用。胰岛素样生长因子以高度特异性和亲和力与一类称为胰岛素样生长因子结合蛋白（IGFBPs，1至6）的6种结合蛋白结合，这些结合蛋白调节其生物活性。大多数已知的胰岛素样生长因子作用是通过1型胰岛素样生长因子受体（IGF1R）介导的。在本文中，我们将综述生长激素-胰岛素样生长因子轴的组成和调节，以及各组分在生长过程调节中的作用。
