Jessen Christian, Agerbaek Mads, Von Der Maase Hans
Department of Oncology, Aarhus University Hospital, Aarhus Sygehus, Nørrebrogade 44, Aarhus C, Denmark.
Acta Oncol. 2009;48(3):411-7. doi: 10.1080/02841860802325932.
The study was undertaken to identify pre-treatment clinical and histopathological factors of importance for response and survival after cisplatin-based combination chemotherapy, in patients with locally advanced or metastatic transitional cell carcinoma of the urothelium.
Clinical, laboratory and histopathological data from 178 consecutive patients, representing all patients treated between 1991 and 2001 in a single institution, were collected. Correlations between these data and response and survival after chemotherapy were analysed using univariate and multivariate analyses.
Absence of visceral metastasis was the only parameter with independent correlation to the response to chemotherapy. Two of the analysed parameters were independently associated with increased survival: good performance status (PS< or =1) and absence of visceral metastases. Stratification of the patient material according to number of these risk-factors present showed strong association with survival.
It was possible to predict survival from pre-treatment clinical parameters and consequently it is possible to select groups with a high and low probability of obtaining long term survival following cisplatin-containing chemotherapy.
本研究旨在确定对于局部晚期或转移性尿路上皮移行细胞癌患者，基于顺铂的联合化疗后反应和生存具有重要意义的治疗前临床和组织病理学因素。
收集了178例连续患者的临床、实验室和组织病理学数据，这些患者代表了1991年至2001年在单一机构接受治疗的所有患者。使用单变量和多变量分析来分析这些数据与化疗后反应和生存之间的相关性。
无内脏转移是与化疗反应独立相关的唯一参数。所分析的参数中有两个与生存率提高独立相关：良好的体能状态（PS≤1）和无内脏转移。根据存在的这些危险因素数量对患者材料进行分层显示与生存率密切相关。
从治疗前临床参数预测生存是可能的，因此有可能选择在含顺铂化疗后获得长期生存可能性高和低的组。
