Poeta Patricia, Radhouani Hajer, Sargo Roberto, Igrejas Gilberto
University of Trás-os-Montes and Alto Douro, Department of Veterinary Sciences, Vila Real, Portugal.
J Basic Microbiol. 2008 Dec;48(6):526-8. doi: 10.1002/jobm.200800146.
Dalbavancin is a new new semisynthetic teicoplanin-related lipoglycopeptide with activity against gram-positive organisms. We investigated the activity of dalbavancin against faecal enterococci isolates from wild animals, pets, poultry and healthy humans in Portugal. The in vitro activity of dalbavancin was determined by the microbroth dilution method according to the Clinical Laboratory Standards Institute (CLSI) guidelines in 589 enterococci of different species and origins. All vancomycin-susceptible Enterococcus spp. were inhibited by < or =0.25 mg/l dalbavancin. Although vancomycin-resistant-enterococci (VRE) showed higher dalbavancin MIC values (16 mg/l), the isolates that exhibited the VanC resistance phenotype were inhibited at dalbavancin concentrations < or =0.125 mg/l. Only van A isolates were not inhibited by low concentrations of dalbavancin since van A strains showed higher dalbavancin MIC values (16 mg/l).
达巴万星是一种新型半合成的与替考拉宁相关的脂糖肽，对革兰氏阳性菌具有活性。我们研究了达巴万星对葡萄牙野生动物、宠物、家禽和健康人类粪便中分离出的肠球菌的活性。根据临床实验室标准协会（CLSI）指南，采用微量肉汤稀释法测定了达巴万星对589株不同种类和来源的肠球菌的体外活性。所有对万古霉素敏感的肠球菌属均被≤0.25mg/L的达巴万星抑制。虽然耐万古霉素肠球菌（VRE）的达巴万星MIC值较高（16mg/L），但表现出VanC耐药表型的分离株在达巴万星浓度≤0.125mg/L时被抑制。只有VanA分离株不受低浓度达巴万星的抑制，因为VanA菌株的达巴万星MIC值较高（16mg/L）。
