血清类黏蛋白（ORM 1）分型与形式遗传学。
Orosomucoid (ORM 1) subtyping and formal genetics.
作者信息
Luckenbach C, Kömpf J, Ritter H
机构信息
Institut für Anthropologie und Humangenetik der Universität, Tübingen, Federal Republic of Germany.
出版信息
Hum Genet. 1991 Aug;87(4):429-32. doi: 10.1007/BF00197162.
Orosomucoid (ORM) phenotyping has been performed in 141 families with 407 children from southwest Germany. Eight families were observed in which duplicated ORM1 genes, F1F2, F1F3, segregated. The family data gave no information about the presence of tandemly duplicated ORM1 F1F4 and ORM1 F1F5 genes. To date, the segregation of the phenotypes of the children agrees with the extended formal model: two ORM1 loci with two common (*F1, *S) and several rare (*F1F2, *F1F3, *F4, *F5) alleles. The parental allele frequencies were calculated by gene counting as ORM1 *F1 = 0.5781, *S = 0.3901, *F1F2 = 0.0195, *F4 = 0.0053, *F1F3 = 00.0035, *F5 = 0.0035.
已对来自德国西南部的141个家庭中的407名儿童进行了血清类粘蛋白（ORM）表型分析。观察到8个家庭中存在重复的ORM1基因F1F2、F1F3的分离情况。家庭数据未提供关于串联重复的ORM1 F1F4和ORM1 F1F5基因存在情况的信息。迄今为止，儿童表型的分离情况与扩展的形式模型相符：两个ORM1基因座具有两个常见等位基因（*F1、*S）和几个罕见等位基因（*F1F2、*F1F3、*F4、*F5）。通过基因计数计算得出亲代等位基因频率为ORM1 *F1 = 0.5781，*S = 0.3901，*F1F2 = 0.0195，*F4 = 0.0053，*F1F3 = 0.0035，*F5 = 0.0035。
Zotero 插件