Bachar Gideon, Goldstein David P, Shah Manish, Tandon Asheesh, Ringash Jolie, Pond Gregory, Gullane Patrick J, Perez-Ordonez Bayardo, Gilbert Ralph W, Brown Dale H, Gentili Fred, O'Sullivan Brian, Irish Jonathan C
Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada.
Head Neck. 2008 Dec;30(12):1607-14. doi: 10.1002/hed.20920.
Esthesioneuroblastoma is rare. The aim of the study was to review our experience and to evaluate the staging system and treatment that best correlates with the patient outcome.
Thirty-nine patients were identified between 1972 and 2006.
At presentation 10% had cervical metastases. None had distant metastasis. Five were treated with surgery, 2 with chemotherapy, 1 with radiotherapy, and 30 with surgery and radiation. Local disease control was 82.6% at 5 years. Recurrence was seen in 33% with local and regional disease recurrence at 15% and 18%, respectively. The 5- and 10-year overall survival rates were 87.9% and 69.2%, respectively. Dulguerov classification correlated most closely to survival and recurrence.
Dulguerov classification best correlates with the patient's outcome. A combined approach is the preferred treatment. It makes no difference whether radiotherapy is given pre or postsurgical resection. Recurrence can occur even 15 years after treatment. Therefore, long-term follow-up is essential.
嗅神经母细胞瘤较为罕见。本研究的目的是回顾我们的经验，并评估与患者预后最相关的分期系统和治疗方法。
确定了1972年至2006年间的39例患者。
初诊时10%的患者有颈部转移。无远处转移。5例接受手术治疗，2例接受化疗，1例接受放疗，30例接受手术和放疗。5年时局部疾病控制率为82.6%。局部和区域疾病复发率分别为15%和18%，总复发率为33%。5年和10年总生存率分别为87.9%和69.2%。杜尔格罗夫分类与生存和复发的相关性最为密切。
杜尔格罗夫分类与患者预后的相关性最佳。联合治疗是首选治疗方法。术前或术后放疗并无差异。甚至在治疗15年后仍可能发生复发。因此，长期随访至关重要。
