Koc Erol, Arca Ercan, Surucu Baris, Kurumlu Zafer
Department of Dermatology, School of Medicine Etlik, Gulhane Military Medical Academy, Ankara, Turkey.
Dermatol Surg. 2008 Nov;34(11):1507-14. doi: 10.1111/j.1524-4725.2008.34314.x. Epub 2008 Sep 15.
Various treatment regimens have been used in scars. The literature offers little consensus about appropriate therapy.
To compare intralesional triamcinolone acetonide (TAC) alone or combined with onion extract in keloidal and hypertrophic scars.
Fourteen patients were treated with intralesional TAC and onion extract gel, and 13 patients were treated with intralesional TAC alone. Findings were recorded and graded at each visit (weeks 0, 4, 12, and 20). The scores before treatment and at week 20 were compared.
Twenty-seven patients [17 men (63%) and 10 women (37%) aged 15 to 73 (average age 28.1 +/- 11.7)] were enrolled in the study. At baseline, the difference in the two treatment groups was not statistically significant (p>.05). At week 20, there was statistically significant improvement in both treatment groups (p<.05). TAC with onion extract was more effective than TAC alone in terms of pain-sensitiveness, itching, and elevation but not in erythema and induration. Treatment was well tolerated, without any adverse effect.
Treatment with intralesional TAC and onion extract and TAC alone were effective. Combined with onion extract gel, intralesional TAC appears to be superior to TAC alone in the treatment of keloids and hypertrophic scars.
瘢痕治疗采用了多种治疗方案。关于何种治疗方案恰当，文献中几乎没有达成共识。
比较曲安奈德（TAC）皮损内注射单独使用或联合洋葱提取物治疗瘢痕疙瘩和增生性瘢痕的效果。
14例患者接受皮损内注射TAC联合洋葱提取物凝胶治疗，13例患者仅接受皮损内注射TAC治疗。每次随访（第0、4、12和20周）时记录结果并进行分级。比较治疗前和第20周时的评分。
27例患者[17例男性（63%）和10例女性（37%），年龄15至73岁（平均年龄28.1±11.7岁）]纳入本研究。基线时，两个治疗组之间的差异无统计学意义（p>0.05）。在第20周时，两个治疗组均有统计学意义的改善（p<0.05）。联合洋葱提取物的TAC在疼痛敏感性、瘙痒和隆起方面比单独使用TAC更有效，但在红斑和硬结方面并非如此。治疗耐受性良好，无任何不良反应。
皮损内注射TAC联合洋葱提取物以及单独使用TAC治疗均有效。皮损内注射TAC联合洋葱提取物凝胶在治疗瘢痕疙瘩和增生性瘢痕方面似乎优于单独使用TAC。
