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曲安奈德在瘢痕成熟过程中的作用

Role of Triamcinolone Acetonide in the Maturation of Scars.

作者信息

Bhosale Ranjit, Dawar Rakesh, Manas Raj Kumar

机构信息

From the Plastic and Aesthetic Surgery, Sculpt Sublime, Mumbai, India.

Burn, Plastic, and Reconstructive Surgery, MGM Super Specialty Hospital, Indore, Madhya Pradesh, India.

出版信息

Plast Reconstr Surg Glob Open. 2024 Jul 15;12(7):e5966. doi: 10.1097/GOX.0000000000005966. eCollection 2024 Jul.

Abstract

BACKGROUND

Surgeons have tried various measures to achieve a minimum and aesthetically appealing scars after wound healing at surgical sites. Various regimens have been recommended to minimize scars both intraoperatively and postoperatively. Our study aims to assess the outcome of the injection of triamcinolone acetonide used intraoperatively on a normal surgical suture line.

METHODS

This is a prospective, observational study of 21 patients (divided into test and control groups with a single scar at the same site) treated with or without injection of triamcinolone acetonide, and outcomes were assessed using Vancouver Scar Scale and Stony Brook Scar Evaluation Scale.

RESULTS

We found a significant difference ( > 0.05) between the median of vascularity, pigmentation, and total score on the Vancouver Scar Scale, whereas there was significant difference between height, color, and overall appearance according to the Stony Brook Scar Evaluation Scale between the test and the control group. We could not find a significant difference in outcome with varying, increasing doses of triamcinolone acetonide.

CONCLUSION

A low dose of triamcinolone acetonide is an effective drug that tends to improve the outcome of a scar in terms of vascularity, pigmentation, height, and overall appearance of the postoperative surgical scar and helps in the maturation of a normal scar.

摘要

背景

外科医生尝试了各种措施,以在手术部位伤口愈合后获得最小且美观的疤痕。已经推荐了各种方案来在手术中和术后尽量减少疤痕。我们的研究旨在评估术中在正常手术缝合线上注射曲安奈德的效果。

方法

这是一项前瞻性观察性研究,对21例患者(分为试验组和对照组,同一部位有单个疤痕)进行了是否注射曲安奈德的治疗,并使用温哥华疤痕量表和石溪疤痕评估量表评估结果。

结果

我们发现温哥华疤痕量表上血管分布、色素沉着和总分的中位数之间存在显著差异(>0.05),而根据石溪疤痕评估量表,试验组和对照组在高度、颜色和整体外观方面存在显著差异。我们未发现不同剂量递增的曲安奈德在效果上有显著差异。

结论

低剂量曲安奈德是一种有效药物,在术后手术疤痕的血管分布、色素沉着、高度和整体外观方面倾向于改善疤痕效果,并有助于正常疤痕的成熟。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21eb/11250240/025485ef3f9d/gox-12-e5966-g001.jpg

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