Sperber A D, Morris C B, Greemberg L, Bangdiwala S I, Goldstein D, Sheiner E, Rusabrov Y, Hu Y, Katz M, Freud T, Neville A, Drossman D A
Department of Gastroenterology, Soroka University Medical Center, Beer-Sheva, Israel.
Neurogastroenterol Motil. 2009 Jan;21(1):18-22. doi: 10.1111/j.1365-2982.2008.01186.x.
Although there have been reports that women develop constipation following hysterectomy, previous studies were either retrospective or uncontrolled. The aim of this prospective, controlled study was to assess whether constipation develops after elective hysterectomy. Women undergoing elective gynaecological surgery were compared to matched non-surgery controls at enrollment and 3 and 12 months after surgery. The subset of women who underwent elective hysterectomy was the study group for the present report. Fifty-eight of the 132 elective surgery patients underwent hysterectomy and were compared to 123 controls. There was no difference between the groups at any follow-up point in functional constipation (P = 1.0), frequency of stools (P = 0.92), stool consistency (P = 0.42), straining (P = 0.43), feeling of obstruction (P = 0.6) or need to manually evacuate stool (P = 1.0). Significantly, more hysterectomy patients without baseline pain did develop abdominal pain at 3 or 12 months than non-surgery controls (16.7% vs 3.6%, P = 0.008). We conclude that there was no significant change in bowel habit or stool characteristics in women undergoing hysterectomy even though many developed abdominal pain. This prospective, controlled study challenges existing data regarding the effect of hysterectomy on constipation.
尽管有报道称女性在子宫切除术后会出现便秘,但以往的研究要么是回顾性的,要么是无对照的。这项前瞻性对照研究的目的是评估择期子宫切除术后是否会发生便秘。在入组时以及术后3个月和12个月,将接受择期妇科手术的女性与匹配的非手术对照组进行比较。接受择期子宫切除术的女性亚组是本报告的研究组。132例择期手术患者中有58例接受了子宫切除术,并与123例对照组进行比较。在任何随访点,两组在功能性便秘(P = 1.0)、排便频率(P = 0.92)、大便稠度(P = 0.42)、用力排便(P = 0.43)、梗阻感(P = 0.6)或需要手动排便(P = 1.0)方面均无差异。值得注意的是,与非手术对照组相比,在3个月或12个月时,更多无基线疼痛的子宫切除患者出现了腹痛(16.7% 对3.6%,P = 0.008)。我们得出结论,尽管许多接受子宫切除术的女性出现了腹痛,但她们的排便习惯或大便特征没有显著变化。这项前瞻性对照研究对现有关于子宫切除术对便秘影响的数据提出了挑战。