Khalique T, Hasan S A, Hasan M
Department of Otorhinolaryngology, J.N. Medical College, Aligarh Muslim University.
Indian J Med Res. 1991 Apr;94:156-60.
The central auditory toxicity of sisomicin was studied in guineapigs administered sisomicin (135 mg/kg body weight) sc for 10 days. Total lipids, phospholipids and cholesterol were estimated in the pons, inferior colliculus, medial geniculate body and auditory cortex. While the total lipids were increased in a non-preferential manner in all the regions studied, phospholipids and cholesterol levels registered no change. This study suggests the possible central auditory toxicity following sisomicin administration.
在给予豚鼠链霉素（135mg/kg体重）皮下注射10天的情况下，研究了链霉素的中枢听觉毒性。测定了脑桥、下丘、内侧膝状体和听觉皮层中的总脂质、磷脂和胆固醇。虽然在所研究的所有区域中总脂质均以非特异性方式增加，但磷脂和胆固醇水平未发生变化。本研究提示链霉素给药后可能存在中枢听觉毒性。
