Liu Xue Q, Hart Derek N J, MacPherson Gordon G, Good Michael F, Wykes Michelle N
Queensland Institute of Medical Research, The Bancroft Centre, Brisbane, Qld, Australia.
Immunology. 2008 Sep;125(1):14-20. doi: 10.1111/j.1365-2567.2008.02914.x.
The development and maintenance of memory B cells (MBC) is dependent on germinal centres (GC) with follicular dendritic cell (FDC) networks. We have previously shown that FDC networks within GC of the spleen express a novel ligand for CD38 and that the administration of soluble CD38 induces an expansion of these cellular structures. We therefore used adoptive transfer studies to investigate whether the expansion of FDC networks with soluble CD38 affected the generation and maintenance of antigen-specific MBC. These studies found that the administration of soluble CD38 significantly extended the period after which MBC could be activated and that the frequencies of these cells also were increased. In conclusion, soluble CD38 appears to significantly extend the lifespan of antibody memory by increasing the numbers of MBC.
记忆B细胞（MBC）的发育和维持依赖于具有滤泡树突状细胞（FDC）网络的生发中心（GC）。我们之前已经表明，脾脏GC内的FDC网络表达一种新型的CD38配体，并且可溶性CD38的给药会诱导这些细胞结构的扩张。因此，我们采用过继转移研究来探究可溶性CD38介导的FDC网络扩张是否会影响抗原特异性MBC的产生和维持。这些研究发现，可溶性CD38的给药显著延长了MBC能够被激活的时间，并且这些细胞的频率也增加了。总之，可溶性CD38似乎通过增加MBC的数量显著延长了抗体记忆的寿命。
