捷他辛A及其类似物的合成与杀线虫活性
Synthesis and nematocidal activities of jietacin A and its analogs.
作者信息
Tsuzuki K, Yan F S, Otoguro K, Omura S
机构信息
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1991 Jul;44(7):774-84. doi: 10.7164/antibiotics.44.774.
PMID:1880067
Abstract
Simple, efficient syntheses of jietacin A, a nematocidal antibiotic, and its analogs have been developed in order to study structure-activity relationships. A series of alpha,beta-unsaturated azoxy compounds was prepared from phenylselenomethyl azoxy compounds as key intermediates and its nematocidal activity was determined.
摘要
为了研究结构-活性关系，已开发出简单、高效的杀线虫抗生素杰他辛A及其类似物的合成方法。以苯硒甲基氧化偶氮化合物为关键中间体，制备了一系列α,β-不饱和氧化偶氮化合物，并测定了其杀线虫活性。
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