Inoue Akemi, Moriya Hiromitsu, Katada Natsuya, Tanabe Satoshi, Kobayashi Nobuyuki, Watanabe Masahiko, Okayasu Isao, Ohbu Makoto
Department of Biological Structure, Kitasato University Graduate School of Medical Sciences, Kitasato, Kanagawa, Japan.
Pathol Int. 2008 Oct;58(10):611-9. doi: 10.1111/j.1440-1827.2008.02279.x.
The clinical and pathological significance of intratumoral lymphangiogenesis (ITL) with human esophageal squamous cell carcinomas (ESCC) remains unclear, as does the role of signaling molecules such as vascular endothelial growth factor (VEGF)-A,C, platelet-derived growth factor (PDGF)-A, and p53, in the regulation of ITL. Lymphatic vessel density (LVD) was significantly increased in VEGF-A and VEGF-C immunohistochemical score 1 and 2-3 groups as compared to the score 0 group and also with high of VEGF-A, VEGF-C and PDGF-A mRNA expression. Both LVD and blood vessel density (BVD) were significantly greater in the p53 gene mutant group than in the wild-type group. Lymph node metastasis was significantly more frequent with than without ITL and Kaplan-Meier analysis indicated a significantly poorer prognosis. Multivariate analysis using Cox proportional hazard method showed that invasion depth, lymph node metastasis and ITL were independent prognostic factors.
肿瘤内淋巴管生成（ITL）在人类食管鳞状细胞癌（ESCC）中的临床和病理意义仍不明确，血管内皮生长因子（VEGF）-A、C、血小板衍生生长因子（PDGF）-A和p53等信号分子在ITL调节中的作用也不明确。与免疫组化评分为0的组相比，VEGF-A和VEGF-C免疫组化评分为1以及2 - 3的组中淋巴管密度（LVD）显著增加，且VEGF-A、VEGF-C和PDGF-A mRNA表达水平较高时也是如此。p53基因突变异组的LVD和血管密度（BVD）均显著高于野生型组。有ITL的淋巴结转移明显比没有ITL的更频繁，Kaplan-Meier分析表明预后明显更差。使用Cox比例风险法进行的多变量分析显示，浸润深度、淋巴结转移和ITL是独立的预后因素。
