Dynamic resolution of N-Boc-2-lithiopiperidine.

作者信息

Coldham Iain, Raimbault Sophie, Chovatia Praful T, Patel Jignesh J, Leonori Daniele, Sheikh Nadeem S, Whittaker David T E

机构信息

Department of Chemistry, University of Sheffield, Sheffield, UKS3 7HF.

出版信息

Chem Commun (Camb). 2008 Sep 21(35):4174-6. doi: 10.1039/b810988e. Epub 2008 Aug 8.

DOI:10.1039/b810988e

PMID:18802520

Abstract

Dynamic thermodynamic resolution of N-Boc-2-lithiopiperidine is possible using a chiral ligand; the two enantiomers of this organolithium can be resolved with selectivities of up to 85 : 15 from a selection of 26 chiral diamino-alkoxide ligands screened.

摘要