Pastar Irena, Stojadinovic Olivera, Tomic-Canic Marjana
Tissue Repair Laboratory, Hospital for Special Surgery of the Weill, Cornell Medical College, New York, NY, USA.
Surg Technol Int. 2008;17:105-12.
Keratinocytes are the major cellular component of epidermis, and they have several critical roles in the wound healing process. They are involved in the intricate mechanisms of initiation, maintenance, and completion of wound healing. The properties of keratinocytes vary depending upon their location and circumstances within chronic wounds. Keratinocytes at the non-healing edges of chronic wounds differ from normal, healthy keratinocytes. The cross-talk between healthy keratinocytes and other cell types participating in wound healing is critical for successful wound closure. This discovery provides the biological foundation for debridement: Removing "bad" cells from a quiescent wound edge and exposing or even replacing them with "healthy" cells with a high regenerative potential can enhance epithelialization and healing of chronic wounds. This paper will review the biological and pathological properties of keratinocytes as they relate to wound healing, and the ways in which they may provide highly efficacious therapy for patients with chronic wounds.
角质形成细胞是表皮的主要细胞成分，它们在伤口愈合过程中发挥着几个关键作用。它们参与伤口愈合起始、维持和完成的复杂机制。角质形成细胞的特性因其在慢性伤口中的位置和环境而异。慢性伤口不愈合边缘的角质形成细胞与正常健康的角质形成细胞不同。健康角质形成细胞与参与伤口愈合的其他细胞类型之间的相互作用对于伤口的成功闭合至关重要。这一发现为清创术提供了生物学基础：从静止的伤口边缘去除“坏”细胞，并用具有高再生潜力的“健康”细胞进行暴露甚至替换，可以促进慢性伤口的上皮形成和愈合。本文将综述角质形成细胞与伤口愈合相关的生物学和病理学特性，以及它们为慢性伤口患者提供高效治疗的方式。
