Yoshioka Ryuji, Okabayashi Takehiro, Nishimori Isao, Maeda Nagamasa, Sugimoto Takeki, Kohsaki Takuhiro, Onishi Saburo, Fukaya Takao, Kobayashi Michiya, Hanazaki Kazuhiro
Kochi Medical School, Nankoku, Kochi, Japan.
Surg Technol Int. 2008;17:192-4.
A61-year-old postmenopausal woman with ovarian carcinoma was treated with two surgical operations and a series of platinum-based chemotherapy. A solitary metastasis into the splenic parenchyma was identified 33 months after the second surgery by abdominal computed tomography with an increased serum level of CA-125. She underwent a pancreaticosplenectomy and received platinum-based adjuvant chemotherapy continuously for 2 years. Her serum CA-125 level decreased to a normal range and she has lived without any recurrence for more than 10 years after the splenectomy. Solitary metastases from ovarian cancer into the splenic parenchyma are extremely rare. Among 18 cases previously reported, this present case shows the longest disease-free survival. Because these cases show favorable prognosis after splenectomy, surgical treatment should be considered along with adjuvant chemotherapy.
一名61岁的绝经后卵巢癌女性接受了两次手术及一系列铂类化疗。第二次手术后33个月,腹部计算机断层扫描发现脾实质有一处孤立转移灶,同时血清CA-125水平升高。她接受了胰脾切除术,并连续接受铂类辅助化疗2年。她的血清CA-125水平降至正常范围,脾切除术后已存活超过10年且无任何复发。卵巢癌孤立转移至脾实质极为罕见。在先前报道的18例病例中,本病例显示出最长的无病生存期。由于这些病例脾切除术后预后良好,应考虑手术治疗并联合辅助化疗。