Lv Meiling, Li Yuyao, Luo Changqin, Liu Peijun, Yang Jin
Department of Clinical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710061, P.R. China.
Clinical and Translational Science Center, The First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710061, P.R. China.
Exp Ther Med. 2014 Apr;7(4):982-986. doi: 10.3892/etm.2014.1500. Epub 2014 Jan 24.
Splenic metastasis of ovarian cancer appears to be more common in serous cystadenocarcinomas. Splenic metastasis usually occurs postoperatively and simultaneously with dissemination to the greater omentum and pelvic cavity. Compared with other ovarian cancer subtypes, ovarian clear cell adenocarcinoma (OCCA) is rare, accounting for <5% of all ovarian malignancies. OCCA has a distinct histological type with poor prognosis and resistance to platinum-based chemotherapy. In the present study, a case of isolated splenic metastasis of OCCA was reported. A 53-year-old female presented with a mass in the left upper quadrant without any other clinical manifestations. Subsequent abdominal and pelvic computed tomography scans revealed multiple mixed cystic-solid lesions, potentially predicting ovarian malignancy. Pathological tests following ovarian cytoreductive surgery revealed primary OCCA with metastases to the spleen. The current study also reviewed recently published literature on splenic metastasis of ovarian carcinoma and demonstrated that the reported case was a rare case of isolated splenic metastasis of OCCA.
卵巢癌的脾转移在浆液性囊腺癌中似乎更为常见。脾转移通常发生在术后，且与大网膜和盆腔播散同时出现。与其他卵巢癌亚型相比，卵巢透明细胞腺癌（OCCA）较为罕见，占所有卵巢恶性肿瘤的比例不到5%。OCCA具有独特的组织学类型，预后较差且对铂类化疗耐药。在本研究中，报告了1例OCCA孤立性脾转移病例。一名53岁女性因左上腹肿块就诊，无任何其他临床表现。随后的腹部和盆腔计算机断层扫描显示多个混合性囊实性病变，可能提示卵巢恶性肿瘤。卵巢肿瘤细胞减灭术后的病理检查显示原发性OCCA伴脾转移。本研究还回顾了最近发表的关于卵巢癌脾转移的文献，并表明该报告病例是1例罕见的OCCA孤立性脾转移病例。
