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乳头肌重新排列的手术性心室修复中期结果:为扩大的缺血性左心室带来额外益处。

Medium-term results of surgical ventricular restoration with papillary muscle realignment: providing additional benefits in enlarged ischemic left ventricle.

作者信息

Nair R Unnikrishnan, Barker Diane, Kumar Sanjay, Javengula Kayala, Tan Lip Bun

机构信息

Department of Cardiac Surgery, Yorkshire Heart Centre, Leeds General Infirmary, Leeds, UK.

出版信息

Surg Technol Int. 2008;17:222-6.

Abstract

In 2001, we described a new surgical technique of surgical ventricular restoration (SVR) in severe heart failure by papillary muscle re-alignment and volume reduction. This procedure has been offered in our institution to patients with severely impaired left ventricular function. Here we examine our mid-term results and also compare them with a similar cohort of patients who had coronary artery bypass grafting (CABG) only. Between 1998 and 2005, 30 patients underwent SVR by papillary muscle realignment with coronary artery revascularization at our institution. A subset of 20 patients had their left ventricular volume measured by echocardiogram and MRI scan, and a maximal cardiopulmonary exercise test was performed before and after the operation. An unselected consecutive cohort of patients with matching age, gender, and hemodynamic status who underwent CABG only without SVR was tested using the same protocol and the results were compared. We noticed that there was a significant advantage for patients who had additional SVR over patients who had CABG only. The observed improvement in those who had SVR may be due to reduced metabolic mismatch as a result of reduced wall tension and normalization of the apical twist of the left ventricle. We believe this would provide a form of surgical treatment for heart failure secondary to ischemic cardiomyopathy at a time of reduced donor organ availability for transplant.

摘要

2001年,我们描述了一种用于治疗严重心力衰竭的新手术技术——手术性心室修复(SVR),该技术通过乳头肌重新排列和容积减小来实现。我们机构已将此手术应用于左心室功能严重受损的患者。在此,我们研究了我们的中期结果,并将其与仅接受冠状动脉旁路移植术(CABG)的类似患者队列进行比较。1998年至2005年期间,我们机构有30例患者通过乳头肌重新排列并进行冠状动脉血运重建接受了SVR手术。其中20例患者通过超声心动图和MRI扫描测量了左心室容积,并在手术前后进行了最大心肺运动试验。对一组未经选择、年龄、性别和血流动力学状态匹配且仅接受CABG而未接受SVR的连续患者队列,采用相同方案进行检测并比较结果。我们注意到,接受额外SVR手术的患者比仅接受CABG手术的患者具有显著优势。接受SVR手术患者观察到的改善可能是由于左心室壁张力降低和心尖扭转正常化导致代谢不匹配减少所致。我们认为,在移植供体器官可用性降低的情况下,这将为缺血性心肌病继发的心力衰竭提供一种手术治疗方式。

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