牛的胚胎干细胞。

Embryonic stem cells in cattle.

作者信息

Muñoz M, Díez C, Caamaño J N, Jouneau A, Hue I, Gómez E

机构信息

Area de Genética y Reproducción, SERIDA, Camino de los Claveles, Gijón, Asturias, Spain.

出版信息

Reprod Domest Anim. 2008 Oct;43 Suppl 4:32-7. doi: 10.1111/j.1439-0531.2008.01229.x.

DOI:10.1111/j.1439-0531.2008.01229.x

PMID:18803754

Abstract

Because of the potential use of embryonic stem cells (ESC), especially for genetic modifications, there is great interest in establishing domestic animals-related ESCs. Unfortunately, despite considerable efforts, validated ESC lines in species other than mice and primates are yet to be isolated. In this paper, we will summarize the current knowledge on bovine ESCs in an attempt to understand why derivation of domestic animal ESC is still unsuccessful and we will discuss some promising future approaches.

摘要

由于胚胎干细胞（ESC）的潜在用途，特别是在基因改造方面，人们对建立与家畜相关的胚胎干细胞有着浓厚的兴趣。不幸的是，尽管付出了巨大努力，但除了小鼠和灵长类动物之外，其他物种中经过验证的胚胎干细胞系尚未分离出来。在本文中，我们将总结关于牛胚胎干细胞的现有知识，试图理解为什么家畜胚胎干细胞的衍生仍然不成功，并且我们将讨论一些未来有前景的方法。