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Preserved DNA from past clinical trials yields new information about a subtype of alcoholism.

作者信息

O'Brien Charles P

出版信息

Curr Psychiatry Rep. 2008 Oct;10(5):375-6. doi: 10.1007/s11920-008-0060-z.

DOI:10.1007/s11920-008-0060-z
PMID:18803909
Abstract
摘要

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Preserved DNA from past clinical trials yields new information about a subtype of alcoholism.从过去临床试验中保存下来的DNA产生了关于一种酒精中毒亚型的新信息。
Curr Psychiatry Rep. 2008 Oct;10(5):375-6. doi: 10.1007/s11920-008-0060-z.
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An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study.评估μ-阿片受体（OPRM1）作为纳曲酮治疗酒精依赖反应预测指标的研究：酒精依赖联合药物治疗与行为干预（COMBINE）研究结果
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Pharmacogenetics of alcoholism: a clinical neuroscience perspective.酒精中毒的药物遗传学：临床神经科学视角
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Predicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators.利用基因指标预测纳曲酮和阿坎酸对酒精依赖患者的疗效。
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COMBINE genetics study: the pharmacogenetics of alcoholism treatment response: genes and mechanisms.联合遗传学研究：酒精成瘾治疗反应的药物遗传学：基因与机制
J Stud Alcohol Suppl. 2005 Jul(15):56-64; discussion 33. doi: 10.15288/jsas.2005.s15.56.
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Am Fam Physician. 2011 Nov 1;84(9):990-2.
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Opioid antagonists for pharmacological treatment of alcohol dependence - a critical review.用于酒精依赖药物治疗的阿片类拮抗剂——一项批判性综述。
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International update: new findings on promising medications.国际最新消息：有前景药物的新发现
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Acamprosate and naltrexone treatment for alcohol dependence: an evidence-based risk-benefits assessment.阿坎酸和纳曲酮治疗酒精依赖：基于证据的风险效益评估。
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Use of acamprosate and opioid antagonists in the treatment of alcohol dependence: a European perspective.阿坎酸和阿片类拮抗剂在酒精依赖治疗中的应用：欧洲视角
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本文引用的文献

1
Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers.阿片受体基因变异对重度饮酒者纳美芬靶向治疗的影响。
Alcohol Clin Exp Res. 2008 Jul;32(7):1159-66. doi: 10.1111/j.1530-0277.2008.00735.x.
2
Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study.纳曲酮对酒精敏感性及药物反应的基因调节因素的影响：一项双盲安慰剂对照研究。
Arch Gen Psychiatry. 2007 Sep;64(9):1069-77. doi: 10.1001/archpsyc.64.9.1069.
3
Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study.
阿片受体基因（OPRM1、OPRK1和OPRD1）变异与纳曲酮治疗酒精依赖的反应：退伍军人事务部合作研究的结果
Alcohol Clin Exp Res. 2007 Apr;31(4):555-63. doi: 10.1111/j.1530-0277.2007.00339.x.
4
The status of naltrexone in the treatment of alcohol dependence: specific effects on heavy drinking.纳曲酮在酒精依赖治疗中的地位：对重度饮酒的特定影响。
J Clin Psychopharmacol. 2006 Dec;26(6):610-25. doi: 10.1097/01.jcp.0000245566.52401.20.
5
Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial.酒精依赖的联合药物治疗与行为干预：综合疗法研究：一项随机对照试验
JAMA. 2006 May 3;295(17):2003-17. doi: 10.1001/jama.295.17.2003.
6
Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden.瑞典中部与酒精依赖相关的功能性μ-阿片受体基因多态性导致的归因风险增加。
Neuropsychopharmacology. 2005 Feb;30(2):417-22. doi: 10.1038/sj.npp.1300598.
7
Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1).阿片类药物阻断后皮质醇反应与μ-阿片受体基因座（OPRM1）Asn40Asp多态性之间的关联。
Am J Med Genet B Neuropsychiatr Genet. 2003 Apr 1;118B(1):60-5. doi: 10.1002/ajmg.b.10054.
8
Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism.内源性阿片系统对高酒精摄入量及酒精成瘾遗传易感性的影响。
J Psychiatry Neurosci. 2001 Sep;26(4):304-18.
9
Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens.纳曲酮对乙醇强化行为的抑制作用与乙醇诱导的伏隔核透析液多巴胺水平升高的减弱有关。
J Neurosci. 1998 Dec 15;18(24):10663-71. doi: 10.1523/JNEUROSCI.18-24-10663.1998.
10
Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction.人类μ阿片受体基因中的单核苷酸多态性改变β-内啡肽结合与活性：对阿片类成瘾的潜在影响。
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9608-13. doi: 10.1073/pnas.95.16.9608.