WASp被一种细菌效应蛋白进行身份盗窃。
WASp identity theft by a bacterial effector.
作者信息
Daugherty-Clarke Karen, Goode Bruce L
机构信息
Rosenstiel Basic Medical Sciences Research Center, Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA.
Rosenstiel Basic Medical Sciences Research Center, Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA.
出版信息
Dev Cell. 2008 Sep;15(3):333-334. doi: 10.1016/j.devcel.2008.08.010.
EspF(U), a protein secreted by pathogenic enterohaemorrhagic E. coli (EHEC), activates N-WASp/WASp to induce actin pedestal formation in host cells. Two recent papers in Nature show that EspF(U) exploits a WASp activation strategy so extreme that it may effectively sequester WASp, blinding it to both autoinhibition and cellular regulation.
EspF(U)是一种由致病性肠出血性大肠杆菌（EHEC）分泌的蛋白质，它激活N-WASp/WASp以诱导宿主细胞中肌动蛋白基座的形成。《自然》杂志最近发表的两篇论文表明，EspF(U)采用了一种极其极端的WASp激活策略，以至于它可能有效地隔离WASp，使其对自身抑制和细胞调节都无动于衷。
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