Kishi Taro, Kitajima Tsuyoshi, Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Ozaki Norio, Iwata Nakao
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
Neurosci Res. 2008 Dec;62(4):211-5. doi: 10.1016/j.neures.2008.08.008. Epub 2008 Aug 30.
Several investigations have suggested that alterations in circadian rhythms may lay the foundation for the development of mood disorder (bipolar disorder and major depressive disorder). Recently, the nuclear receptor Rev-erb alpha was reported to be related to circadian rhythms, and was shown to be involved in the biological action of lithium in vitro. These evidences indicate that the nuclear receptor Rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of mood disorders. To evaluate the association between NR1D1 and mood disorders, we conducted a case-control study of Japanese samples (147 bipolar patients, 322 major depressive disorder patients and 360 controls) with three tagging SNPs selected by HapMap database. One SNP showed an association with bipolar disorder in females. After Bonferroni correction for multiple testing, however, this significance disappeared. No significant association was found with major depressive disorder. In conclusion, our findings suggest that NR1D1 does not play a major role in the pathophysiology of mood disorders in the Japanese population.
多项研究表明，昼夜节律的改变可能为情绪障碍（双相情感障碍和重度抑郁症）的发展奠定基础。最近，有报道称核受体Rev-erbα与昼夜节律有关，并且在体外实验中显示其参与锂的生物学作用。这些证据表明，核受体Rev-erbα基因（NR1D1）是情绪障碍发病机制的一个良好候选基因。为了评估NR1D1与情绪障碍之间的关联，我们对日本样本（147例双相情感障碍患者、322例重度抑郁症患者和360例对照）进行了病例对照研究，采用了由HapMap数据库选择的三个标签单核苷酸多态性（tagging SNPs）。其中一个单核苷酸多态性在女性双相情感障碍患者中显示出关联。然而，在对多重检验进行Bonferroni校正后，这种显著性消失了。未发现与重度抑郁症有显著关联。总之，我们的研究结果表明，在日本人群中，NR1D1在情绪障碍的病理生理学中不发挥主要作用。
