Int J Cardiol. 2009 Oct 2;137(2):e29-32. doi: 10.1016/j.ijcard.2008.05.052. Epub 2008 Sep 19.
A 49-year-old male became hypotensive, bradycardic, and suffered myocardial injury during induction of anesthesia with lidocaine, propofol, and rocuronium in the operating room. Coronary arteriography revealed coronary vasospasm in coronary arteries otherwise free of disease. In the ICU, the patient was again administered rocuronium for a procedure with subsequent hypotension, bradycardia, and ST elevation on telemetry that resolved with administration of diphenhydramine and hydrocortisone. An allergic reaction to rocuronium with coronary vasospasm is suspected, suggestive of the Type 1 variant of Kounis syndrome. This is the first report to describe a case of rocuronium-induced Type 1 Kounis syndrome.
一名 49 岁男性在手术室接受利多卡因、丙泊酚和罗库溴铵麻醉诱导时出现低血压、心动过缓，并发生心肌损伤。冠状动脉造影显示冠状动脉无病变，但存在血管痉挛。在重症监护病房，患者因再次进行一项操作而使用罗库溴铵，随后出现低血压、心动过缓和遥测心电图 ST 段抬高，给予苯海拉明和氢化可的松后缓解。怀疑罗库溴铵引起的冠状动脉痉挛伴过敏反应为 1 型 Kounis 综合征，这是首例描述罗库溴铵诱导的 1 型 Kounis 综合征的报告。
