Zaccone Giacomo, Mauceri Angela, Maisano Maria, Giannetto Alessia, Parrino Vincenzo, Fasulo Salvatore
Section of Comparative Neurobiology and Biomonitoring, Department of Animal Biology and Marine Ecology, Faculty of Science, University of Messina, Messina, Italy.
Acta Histochem. 2009;111(2):93-103. doi: 10.1016/j.acthis.2008.05.003. Epub 2008 Sep 20.
Anatomical and physiological studies of cardiovascular control are lacking in the ray-finned fish, the bichirs. The present immunohistochemical studies on the bichir (Polypterus bichir bichir) demonstrated the occurrence of intracardiac neurons and nerve fibers in the heart. Immunoreactivity to tyrosine hydroxylase (TH) and acetylcholinesterase (AchE) and various neuropeptides (substance P, galanin, vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP)), including neuronal nitric oxide synthase (nNOS), was found in the nerve cell bodies lying close to the Sinus venosus and the sino-atrial region. The main intracardiac localization of the nervous tissue is a network of nerve fibers, presumably corresponding to the postganglionic outflow giving rise to nerve terminals and the nerve cell bodies. In addition, the heart is innervated by extrinsic monoamine-containing nerve fibers supplying the Conus arteriosus and Sinus venosus, and substance P and galanin immunopositive fibers probably originating from cranial and spinal ganglia. The adrenergic innervation of the heart of the bichir is similar to that of the teleosts, but further studies are required on nervous control of the heart.
在硬骨鱼多鳍鱼中，缺乏对心血管控制的解剖学和生理学研究。目前对多鳍鱼（多鳍鱼）的免疫组织化学研究表明，心脏中存在心内神经元和神经纤维。在靠近静脉窦和窦房区域的神经细胞体中发现了对酪氨酸羟化酶（TH）、乙酰胆碱酯酶（AchE）以及各种神经肽（P物质、甘丙肽、血管活性肠肽（VIP）和垂体腺苷酸环化酶激活肽（PACAP））的免疫反应性，包括神经元型一氧化氮合酶（nNOS）。神经组织在心内的主要定位是一个神经纤维网络，大概对应于产生神经末梢和神经细胞体的节后传出纤维。此外，心脏由供应动脉圆锥和静脉窦的含外源性单胺神经纤维支配，P物质和甘丙肽免疫阳性纤维可能起源于颅神经节和脊神经节。多鳍鱼心脏的肾上腺素能神经支配与硬骨鱼相似，但仍需要对心脏的神经控制进行进一步研究。
