Int J Cardiol. 2010 Mar 4;139(2):206-9. doi: 10.1016/j.ijcard.2008.08.026. Epub 2008 Sep 20.
Stent components acting as potential antigens and promoting intracoronary mast cell activation can lead to catastrophic intrastent thrombosis. Patients with drug-eluting stent (DES) implantation are prone to hypersensitivity reactions from five potential antigens namely, nickel strut, polymer coating, eluted drug, as well as, concomitant drugs clopidogrel and aspirin. These events may be more common than suspected because it is hard to document them, unless they become systemic, in which case they manifest themselves as the Kounis syndrome characterized by the concurrence of acute coronary events with hypersensitivity reactions. This report concerns of a patient with implanted DES who developed an acute myocardial infarction in the stent area following an allergic reaction to contrast material.
支架成分作为潜在的抗原并促进冠状动脉内 mast 细胞激活可导致灾难性的支架内血栓形成。接受药物洗脱支架 (DES) 植入的患者易发生五种潜在抗原（镍支架、聚合物涂层、洗脱药物以及同时使用的药物氯吡格雷和阿司匹林）的过敏反应。这些事件可能比怀疑的更为常见，因为难以记录它们，除非它们成为全身性的，在这种情况下，它们表现为 Kounis 综合征，其特征是急性冠状动脉事件与过敏反应同时发生。本报告涉及一名接受 DES 植入的患者，该患者在对造影剂发生过敏反应后，支架区域发生急性心肌梗死。
