Grootens Koen P, van Luijtelaar Gilles, Miller Christopher A F J, Smits Tim, Hummelen Jacobus W, Buitelaar Jan K, Verkes Robbert J
CW2 Hospital Nijmegen, Department of Psychiatry (A15), P.O. Box 9015, 6500 GS Nijmegen, The Netherlands.
J Neuropsychiatry Clin Neurosci. 2008 Summer;20(3):348-56. doi: 10.1176/jnp.2008.20.3.348.
The authors explore sensory gating deficits in borderline personality disorder patients, such as those described in schizophrenia, in patients with borderline personality disorder. Gating of the P50, N100, and P200 auditory evoked potentials and prepulse inhibition of the startle response (PPI) were measured in borderline patients and a group of healthy comparison subjects. Borderline patients did not show lower sensory gating, but showed higher P50, N100, and P200 gating than comparison subjects. This was mainly due to the increased response after the first stimulus. There were no group differences in PPI. Unlike in other major psychiatric disorders, such as schizophrenia, sensory (motor) gating is intact in borderline personality disorder. The higher early preattentive and mid-latency evoked potentials suggest a higher response tendency in borderline personality disorder, but this needs further replication.
作者探讨了边缘型人格障碍患者的感觉门控缺陷，比如精神分裂症中所描述的那些缺陷，研究对象为边缘型人格障碍患者。对边缘型患者以及一组健康对照者测量了P50、N100和P200听觉诱发电位的门控以及惊跳反应的前脉冲抑制（PPI）。边缘型患者并未表现出较低的感觉门控，而是相较于对照者表现出更高的P50、N100和P200门控。这主要是由于首次刺激后反应增强所致。PPI方面不存在组间差异。与精神分裂症等其他主要精神障碍不同，边缘型人格障碍的感觉（运动）门控是完整的。较高的早期前注意和中潜伏期诱发电位表明边缘型人格障碍有更高的反应倾向，但这需要进一步验证。
