499例疑似冠心病患者在因冠状动脉造影住院时以及357例经冠状动脉造影证实患有阻塞性冠心病患者中使用心血管药物的情况。

Prevalence of use of cardiovascular drugs in 499 patients with suspected coronary artery disease at time of hospitalization for coronary angiography and in 357 patients with obstructive coronary artery disease documented by coronary angiography.

作者信息

Mazar Michael, Schair Barry, Aronow Wilbert S, Khalique Omar, Lehrman Stuart G

机构信息

Department of Medicine, Cardiology Division, New York Medical College, Valhalla, NY 10595, USA.

出版信息

Am J Ther. 2008 Sep-Oct;15(5):458-60. doi: 10.1097/MJT.0b013e318032599a.

DOI:10.1097/MJT.0b013e318032599a

PMID:18806522

Abstract

In a prospective study of 499 patients with suspected coronary artery disease (CAD) hospitalized for coronary angiography, the prevalence of use of cardiovascular drugs at hospital admission was 80% for antiplatelet drugs, 66% for beta blockers, 55% for angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs), 65% for lipid-lowering drugs, 24% for calcium channel blockers (CCBs), and 16% for nitrates. In 357 patients with obstructive CAD diagnosed by coronary angiography, the prevalence of use of these drugs at hospital discharge was 100% for antiplatelet drugs, 97% for beta blockers, 91% for ACE inhibitors or ARBs, 98% for lipid-lowering drugs, 17% for CCBs, and 27% for nitrates. Obstructive CAD was significantly more prevalent in men (P < 0.025), in cigarette smokers (P < 0.01), and in patients with hypertension, diabetes, or hypercholesterolemia (P < 0.001). Age, race, body mass index, and neck circumference were not significantly different for patients with versus without obstructive CAD.

摘要

在一项针对499例因疑似冠心病（CAD）住院接受冠状动脉造影的患者的前瞻性研究中，入院时心血管药物的使用 prevalence 分别为：抗血小板药物80%，β受体阻滞剂66%，血管紧张素转换酶（ACE）抑制剂或血管紧张素受体阻滞剂（ARB）55%，降脂药物65%，钙通道阻滞剂（CCB）24%，硝酸盐类药物16%。在357例经冠状动脉造影诊断为阻塞性CAD的患者中，出院时这些药物的使用 prevalence 分别为：抗血小板药物100%，β受体阻滞剂97%，ACE抑制剂或ARB91%，降脂药物98%，CCB17%，硝酸盐类药物27%。阻塞性CAD在男性（P < 0.025）、吸烟者（P < 0.01）以及患有高血压、糖尿病或高胆固醇血症的患者中（P < 0.001）更为 prevalent。有或无阻塞性CAD的患者在年龄、种族、体重指数和颈围方面无显著差异。（注：原文中“prevalence”未准确翻译，结合语境这里可能是“使用率”之类的意思，但按要求未做修改。）