Wang Hongsheng, Morse Herbert C
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook 1, Rm. 1518, 5640 Fishers Lane, Rockville, MD 20852, USA.
Immunol Res. 2009;43(1-3):109-17. doi: 10.1007/s12026-008-8055-8.
Interferon regulatory factor 8 (IRF8) is a member of the IRF family of transcription factors whose members play critical roles in interferon (IFN) signaling pathways governing the establishment of innate immune responses by myeloid and dendritic cells. IRF8 is also expressed in lymphoid cells and recent studies have documented its involvement in B cell lineage specification, immunoglobulin light chain gene rearrangement, the distribution of mature B cells into the marginal zone and follicular B cell compartment, and the transcriptional regulation of critical elements of the germinal center reaction. Here we review the contributions of IRF8 to B cell development from hematopoietic stem cells in the bone marrow and its place in the hierarchical regulatory network governing specification and commitment to the B cell fate.
干扰素调节因子8（IRF8）是转录因子IRF家族的成员之一，该家族成员在干扰素（IFN）信号通路中发挥关键作用，这些信号通路调控髓样细胞和树突状细胞建立先天免疫反应。IRF8也在淋巴细胞中表达，最近的研究记录了它参与B细胞谱系特化、免疫球蛋白轻链基因重排、成熟B细胞向边缘区和滤泡B细胞区室的分布以及生发中心反应关键元件的转录调控。在此，我们综述IRF8对骨髓中造血干细胞B细胞发育的贡献及其在调控B细胞命运特化和定向的分级调控网络中的地位。
