Tsuchiya Shinichi
Division of Diagnostic Pathology, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
Med Mol Morphol. 2008 Sep;41(3):121-5. doi: 10.1007/s00795-008-0408-9. Epub 2008 Sep 20.
In contrast to invasive ductal carcinoma, invasive lobular carcinoma (ILC) of the breast is characterized by multiple ipsilateral occurrences and a higher incidence in the contralateral breast. It is therefore necessary to examine thoroughly whether there is any other carcinoma present before any breast-conserving surgery is carried out. We cytologically, histologically, and ultrastructurally investigated ILC and pure scirrhous carcinoma (PSC), a subtype of invasive ductal carcinoma, to establish cytological diagnostic criteria for the differential diagnosis of these two types of carcinoma that have high histological similarity. Cytologically, ILC cells showed linear or isolated cell arrangements and had small nuclei with round homogeneously distributed fine granular chromatin. The cytoplasm was light, and individual cells lacked cohesion. The carcinoma showed a rosary-like configuration. PSC cells, however, showed linear or cordlike arrangements. Individual cells showed a vertical arrangement. PSC cells had a linear cytoplasmic edge and were characterized by nuclear molding with coarse granular chromatin. These cytological findings were supported by histological and ultrastructural findings. These findings may contribute to histological estimation of ILC in preoperative cytological diagnosis.
与浸润性导管癌不同，乳腺浸润性小叶癌（ILC）的特征是同侧多灶发生，对侧乳腺发病率较高。因此，在进行任何保乳手术之前，有必要彻底检查是否存在其他癌症。我们对ILC和浸润性导管癌的一种亚型——纯硬癌（PSC）进行了细胞学、组织学和超微结构研究，以建立细胞学诊断标准，用于鉴别这两种组织学相似性高的癌症。在细胞学上，ILC细胞呈线性或孤立的细胞排列，细胞核小，圆形，均匀分布着细颗粒状染色质。细胞质淡染，单个细胞缺乏黏附性。癌呈念珠状结构。然而，PSC细胞呈线性或索状排列。单个细胞呈垂直排列。PSC细胞有线性的细胞质边缘，其特征是核塑形，染色质粗糙呈颗粒状。这些细胞学发现得到了组织学和超微结构发现的支持。这些发现可能有助于术前细胞学诊断中对ILC的组织学评估。
