挪威原发性皮肤T细胞淋巴瘤的发病率。

Incidence of primary cutaneous T-cell lymphoma in Norway.

作者信息

Saunes M, Nilsen T I Lund, Johannesen T B

机构信息

Department of Dermatology, St Olavs Hospital, and Norwegian University of Science and Technology, Trondheim, Norway.

出版信息

Br J Dermatol. 2009 Feb;160(2):376-9. doi: 10.1111/j.1365-2133.2008.08852.x. Epub 2008 Sep 19.

DOI:10.1111/j.1365-2133.2008.08852.x

PMID:18808419

Abstract

BACKGROUND

Studies from different countries have reported an increased incidence of primary cutaneous lymphomas over the last decades.

OBJECTIVES

To estimate the incidence rates of primary cutaneous T-cell lymphoma (CTCL) and mycosis fungoides (MF)/Sézary syndrome (SS) in Norway, and to compare these rates with those reported from other countries.

METHODS

Data from the Cancer Registry of Norway on non-Hodgkin lymphomas during the period 1980-2003 were analysed.

RESULTS

In total, 337 cases of CTCL were reported to the Cancer Registry during the study period, of which 262 cases were classified as MF/SS. The incidence rate of CTCL increased significantly (P(trend) < 0.001) from 0.16 (95% confidence interval, CI 0.11-0.20) per 100,000 person-years in 1980-84 to 0.29 (95% CI 0.22-0.36) per 100,000 person-years in 2000-2003. The incidence of MF/SS also increased during the same period (P(trend) = 0.05) from 0.15 (95% CI 0.10-0.19) per 100,000 person-years to 0.18 (95% CI 0.13-0.24) per 100,000 person-years.

CONCLUSIONS

The incidence of both CTCL and MF/SS increased in Norway during the period 1980-2003.

摘要

背景

来自不同国家的研究报告称，在过去几十年中，原发性皮肤淋巴瘤的发病率有所上升。

目的

估计挪威原发性皮肤T细胞淋巴瘤（CTCL）和蕈样肉芽肿（MF）/赛塞里综合征（SS）的发病率，并将这些发病率与其他国家报告的发病率进行比较。

方法

分析了挪威癌症登记处1980 - 2003年期间非霍奇金淋巴瘤的数据。

结果

在研究期间，癌症登记处共报告了337例CTCL病例，其中262例被归类为MF/SS。CTCL的发病率从1980 - 1984年每10万人年0.16（95%置信区间，CI 0.11 - 0.20）显著增加（P趋势<0.001）至2000 - 2003年每10万人年0.29（95% CI 0.22 - 0.36）。MF/SS的发病率在同一时期也有所增加（P趋势 = 0.05），从每10万人年0.15（95% CI 0.10 - 0.19）增至每10万人年0.18（95% CI 0.13 - 0.24）。