Yasukawa Kana, Kato Naoko, Kodama Kazuo, Hamasaka Asuka, Hata Hiroo
Department of Dermatology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan.
J Cutan Pathol. 2006 Jul;33(7):487-91. doi: 10.1111/j.1600-0560.2006.00460.x.
The relative incidence of malignant lymphoma subtypes differs according to geographic location. This study investigated the epidemiology of cutaneous lymphoma subtypes in Japan and compared it with other countries.
Sixty-two patients with cutaneous lymphoma attending the Department of Dermatology, National Hospital Organization Hokkaido Cancer Center were reviewed. The World Health Organization classification of hematopoietic and lymphoid malignancies was adopted.
Of the 62 patients, 31 had primary cutaneous lymphoma (PCL) and 31 had secondary cutaneous lymphoma (SCL). T- and natural killer (NK)-cell lymphoma accounted for 80% of PCL, of which, mycosis fungoides accounted for almost 35%. Of the 31 patients with secondary cutaneous lymphoma, 17 patients (54%) had T- and NK-cell lymphoma, including nine adult T-cell leukemia/lymphoma patients, and 14 patients (46%) had B-cell lymphoma, including 11 diffuse large B-cell lymphoma patients. The majority of patients with SCL and NK-cell lymphoma with primary or secondary skin lesions had a poor outcome.
PCL in this study showed a similar incidence to that of other institutions in Japan, while also demonstrating different frequencies from that of other countries, suggesting that the relative frequency of different PCL subtypes differ according to geographical location, similar to previous reports of systemic malignant lymphoma.
恶性淋巴瘤亚型的相对发病率因地理位置而异。本研究调查了日本皮肤淋巴瘤亚型的流行病学，并将其与其他国家进行比较。
对北海道国立癌症中心皮肤科就诊的62例皮肤淋巴瘤患者进行回顾性研究。采用世界卫生组织造血与淋巴系统恶性肿瘤分类标准。
62例患者中，31例为原发性皮肤淋巴瘤（PCL），31例为继发性皮肤淋巴瘤（SCL）。T细胞和自然杀伤（NK）细胞淋巴瘤占PCL的80%，其中蕈样肉芽肿约占35%。31例继发性皮肤淋巴瘤患者中，17例（54%）为T细胞和NK细胞淋巴瘤，包括9例成人T细胞白血病/淋巴瘤患者；14例（46%）为B细胞淋巴瘤，包括11例弥漫性大B细胞淋巴瘤患者。大多数原发性或继发性皮肤病变的SCL和NK细胞淋巴瘤患者预后较差。
本研究中的PCL发病率与日本其他机构相似，但与其他国家不同，这表明不同PCL亚型的相对频率因地理位置而异，与先前关于系统性恶性淋巴瘤的报道相似。
