Bilen S, Saka M, Ak F, Oztekin N
2nd Neurology Department of Ankara Numune Training and Research Hospital, Ankara, Turkey.
Intern Med J. 2008 Aug;38(8):672-4. doi: 10.1111/j.1445-5994.2008.01747.x.
Serotonin-selective re-uptake inhibitors are prescribed widely because they are regarded as having less severe side-effects compared with tricyclics and monoamine oxidase inhibitors. With this popularity, increasing attention has been drawn to their adverse effects. Development of extrapyramidal symptoms has been reported in some patients while taking fluoxetine, a commonly used serotonin-selective re-uptake inhibitor. Here, we report a case of persistent dystonia, thought to be associated with short-term fluoxetine use, which required treatment with botulinum toxin type A.
血清素选择性再摄取抑制剂被广泛使用，因为与三环类药物和单胺氧化酶抑制剂相比，它们被认为副作用较轻。随着这种广泛应用，人们对其不良反应的关注日益增加。有报道称，一些患者在服用常用的血清素选择性再摄取抑制剂氟西汀时出现了锥体外系症状。在此，我们报告一例持续性肌张力障碍病例，认为与短期使用氟西汀有关，该病例需要用A型肉毒毒素进行治疗。
