Chaves Paulo H M
Center on Aging and Health, Division of Geriatric Medicine and Gerontology, Departments of Medicine and Epidemiology, Johns Hopkins University, 2024 E. Monument Street, Baltimore, MD, USA.
Semin Hematol. 2008 Oct;45(4):255-60. doi: 10.1053/j.seminhematol.2008.06.005.
Observational studies have consistently documented independent, strong associations of anemia--even if not severe--with major adverse functional outcomes in older adults. In this chapter, recent epidemiologic evidence linking mild anemia with decline in physical and cognitive function, frailty, and disability in community-dwelling older adults is reviewed. Altogether, these biologically plausible associations provide empirical, though not conclusive, support for the notion of mild anemia as a cause of adverse functional outcomes in older adults. Randomized clinical trial data assessing the impact of anemia correction on functional outcomes are lacking at this time.
观察性研究一直记录到，即使不严重，贫血与老年人的主要不良功能结局之间也存在独立且强烈的关联。在本章中，我们回顾了近期将轻度贫血与社区居住老年人的身体和认知功能下降、衰弱及残疾联系起来的流行病学证据。总体而言，这些从生物学角度看似合理的关联为轻度贫血是老年人不良功能结局的一个原因这一观点提供了经验性（尽管不是决定性的）支持。目前缺乏评估纠正贫血对功能结局影响的随机临床试验数据。
