Nagano K, Nakayama N, Tuji Y, Miyazoe H
Department of Pediatrics, Nagasaki Central National Hospital.
Jpn J Antibiot. 1991 May;44(5):543-51.
Laboratory and clinical studies on cefpirome (CPR, HR 810), a newly developed cephem antibiotic, were performed. The results obtained are summarized as follows: 1. Absorption and elimination of the drug were examined in a total of 7 children including 3 cases of administered with 20 mg/kg intravenous bolus injection (i.v.), 2 cases with 20 mg/kg drip infusion (d.i.v.) for 60 minutes and 2 cases with 40 mg/kg (d.i.v.) for 60 minutes. Maximum serum levels were attained immediately after i.v. or d.i.v. Cmax's were 233 +/- 7.6, 88.5 +/- 14.5, and 116 +/- 15 micrograms/ml, respectively for the above 3 modes of administration. These values were determined using a bioassay method with Bacillus subtilis ATCC 6633. T 1/2 (beta)'s were 1.18 +/- 0.17, 1.61 +/- 0.28 and 2.68 +/- 0.83 hours, respectively. Cumulative urinary recovery rates were 40.2-69.8% in a period of 0-6 hours after admissions. 2. Clinical efficacies were evaluated in a total of 20 patients with ages ranging from 9 months to 11 years. The treated cases were 6 cases of acute pneumonia, 4 cases of acute bronchitis, 4 cases of acute purulent tonsillitis, 2 cases of acute urinary tract infections, 2 cases of cellulitis, 1 case of purulent lympadenitis and 1 case of acute otitis media. The clinical efficacy rate was 94.7%. Adverse reactions occurred in no patients. Abnormal changes in laboratory test values involved only 1 case with elevated GOT and GPT. CPR was considered to be a safe and useful drug in treating various infectious diseases in children.
对新开发的头孢匹罗（CPR，HR 810）进行了实验室和临床研究。所得结果总结如下：1. 对总共7名儿童进行了药物吸收和消除研究，其中3例静脉推注20mg/kg，2例静脉滴注20mg/kg持续60分钟，2例静脉滴注40mg/kg持续60分钟。静脉推注或静脉滴注后立即达到最高血清水平。上述3种给药方式的Cmax分别为233±7.6、88.5±14.5和116±15μg/ml。这些值是使用枯草芽孢杆菌ATCC 6633的生物测定法测定的。T 1/2（β）分别为1.18±0.17、1.61±0.28和2.68±0.83小时。入院后0至6小时内累积尿回收率为40.2 - 69.8%。2. 对总共20名年龄在9个月至11岁之间的患者进行了临床疗效评估。治疗病例包括6例急性肺炎、4例急性支气管炎、4例急性化脓性扁桃体炎、2例急性尿路感染、2例蜂窝织炎、1例化脓性淋巴结炎和1例急性中耳炎。临床有效率为94.7%。无患者出现不良反应。实验室检查值异常仅涉及1例GOT和GPT升高。头孢匹罗被认为是治疗儿童各种传染病的一种安全有效的药物。
