Fujimura A, Ohashi K, Ebihara A
Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
Jpn J Pharmacol. 1991 May;56(1):105-8. doi: 10.1254/jjp.56.105.
A new loop diuretic with uricosuric activity, 6,7-dichloro-5-(N,N-dimethylsulfamoyl)-2,3-dihydro-2-benzofuran carboxylic acid (S-8666), was given orally at 12:00 a.m. or 12:00 p.m. in rats. The diuretic of S-8666 and the urinary excretions of the drug and its active metabolite S-8680 (N-demethyl S-8666) were greater at 12:00 a.m. than at 12:00 p.m. Thus, the present study indicates that the diuretic effects of S-8666 varies with its administration time. Time-dependent variations in the amount of urinary excretions of S-8666 and S-8680 might be involved in the mechanisms for this phenomenon.
一种具有促尿酸排泄活性的新型袢利尿剂6,7-二氯-5-(N,N-二甲基氨磺酰基)-2,3-二氢-2-苯并呋喃羧酸(S-8666)，于上午12:00或下午12:00经口给予大鼠。S-8666的利尿作用以及该药物及其活性代谢产物S-8680（N-去甲基S-8666）的尿排泄量在上午12:00时比下午12:00时更高。因此，本研究表明S-8666的利尿作用随给药时间而变化。S-8666和S-8680尿排泄量的时间依赖性变化可能参与了这一现象的机制。
